苏州微流纳米生物技术有限公司

Suzhou Will NanoBioTech Co.,Ltd.
咨询热线: 13020218906  邮箱: biotech@willnano.com
产品详情
药用磷脂辅料
产品名称:药用磷脂辅料

英文名称:Lipid Excipients for Liposome

其它名称:脂质体磷脂胶束辅料

产品型号:粉末

产品品牌:N/A

产品产地:N/A

产品功能:脂质体、胶束、纳米乳、脂肪乳制备组成成分。

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产品详情:

Due to extensive developments in liposome technology in the recent years, a number of liposome-based drug formulations are available in clinic market and many products are under different clinical trials.  

Among them, the liposomes 

for adriamycin are Doxil®, Myocet®, DaunoXome®;  

for Amphotericin B are Abelcet®,  Ambisome®,  Amphotec®;  

The micelle for Paclitaxel are Cynviloq™, Apealea®,  Genexol-PM®.


Application:Liposome Preparation

阿霉素脂质体Doxil磷脂结构示意图紫杉醇胶束


阿霉素脂质体 Myocet             peg修饰脂质体



Formulation

Doxil®              Adriamycin/mL: HSPC: CHOL: DSPE-mPEG2000=2mg: 9.58mg: 3.19mg: 3.19mg; Excipients: Ammonia Sulfate 2mg Histidine 1.55mg Surcrose 94mg

Ambisome®      Amphotericin B: HSPC: CHOL: DSPG=50mg: 213mg: 52mg: 84mg; Excipients: α-Tocopherol 0.64mg Disodium succinate hexahydrate 27mg Sucrose 900mg Water 12mL

Abelcet®          Amphotericin B/mL: DMPC: DMPG=5.0mg: 3.4mg: 1.5mg; Excipients: Sodium Chloride: 9.0mg

Amphotec®      Amphotericin B: Cholesteryl sodium sulfate: Trometamol =50mg: 26.4mg: 5.64mg; Excipients: Disodium edetate 0.372mg Lactose Monohydrate 950mg Water10ml

Genexol-PM®  Paclitaxel: mPEG-PLA=30mg: 150mg

Abraxane®       Paclitaxel: Human Albumin=100mg: 900mg


Specification
NameDescriptionPurity
DSPE-mPEG2000Methoxypolyethylene glycol DSPE (1,2-Distearoyl-sn-Glycero-3-Phosphoethanolamine)≥99.0%
HSPCL-α-phosphatidylcholine, hydro genated (Soy)≥99.0%
DSPG1,2-Distearoyl-sn-glycero-3-phosphoglycerol, sodium salt≥99.0%
DMPC1,2-dimyristoyl-sn-glycero-3-phosphocholine≥99.0%
DMPG1,2-dimyristoyl-sn-glycero-3-phospho-(1'-rac-glycerol) (sodium salt)≥99.0%
CHOCholesterol≥99.0%
Cholesteryl SulfateCholesteryl sodium sulfate≥99.0%
PEG-b-PLAMonomethoxy-Poly(ethylene glycol)-block-poly(d,l-lactic acid)Quote
AdriamycinActive ingradient in Doxil®, Myocet®, DaunoXome® ≥99.0%
PaclitaxelActive ingradient in Abelcet®,  Ambisome®,  Amphotec® ≥99.0%
Amphotericin BActive ingradient in Cynviloq™,  Apealea®,  Genexol-PM® ≥99.0%